ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases Xiaosong Wang1, Yifan Peng 2, Le Lu 1, Zhiyong Lu 2, Mohammadhadi Bagheri 1, Ronald M. Summers 1 1Department of Radiology and Imaging Sciences, Clinical Center, 2 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892 {xiaosong.wang,yifan.peng,le.lu,luzh,mohammad.bagheri,rms}@nih.gov Abstract The chest X-ray is one of the most commonly accessi- ble radiological examinations for screening and diagnosis of many lung diseases. A tremendous number of X-ray imaging studies accompanied by radiological reports are accumulated and stored in many modern hospitals’ Pic- ture Archiving and Communication Systems (PACS). On the other side, it is still an open question how this type of hospital-size knowledge database containing invaluable imaging informatics (i.e., loosel